Highest goal ratio in Premier League history

At least 125 goals scored.

0,678 per game: Thierry Henry

0,669 Sergio "Kun" Agüero

0,666 Harry Kane

0,599 Mo Salah

0,590 Alan Shearer

0,514 Robin van Persie

0,460 Michael Owen

0,452 Andy Cole

0,441 Jamie Vardy, Jimmy Floyd Hasselbaink

0,430 Robbie Fowler

0,425 Les Ferdinand

0,424 Wayne Rooney

0,361 Robbie Keane

0,349 Teddy Sheringham

0,343 Nicolas Anelka

0,327 Jermain Defoe

0,291 Frank Lampard

All time topscorers: England.

Premier League:
260: Alan Shearer (-photo-, Blackburn, Newcastle)
187: Andy Cole (Newcastle, Man Utd, Blackburn, Fulham, Man City, Portsmouth, Birmingham, Sunderland)
176: Thierry Henry (Arsenal)
163: Robbie Fowler (Liverpool, Leeds, Man City, Liverpool, Blackburn)
151: Frank Lampard (West Ham, Chelsea)
149: Les Ferdinand (QPR, Newcastle, Tottenham, West Ham, Leicester, Bolton)
149: Michael Owen (Liverpool, Newcastle, Man Utd)
147: Teddy Sheringham (Nott'm Forest, Tottenham, Man Utd, Tottenham, Portsmouth, West Ham)
144: Wayne Rooney (Everton, Man Utd)
127: Jimmy Floyd Hasselbaink (Leeds, Chelsea, Middlesborough)
126: Robbie Keane (Coventry, Leeds, Tottenham, Liverpool, Tottenham, West Ham, Aston Villa)
123: Dwight Yorke (Aston Villa, Man Utd, Blackburn, Birmingham, Sunderland)
123: Nicolas Anelka (Arsenal, Liverpool, Man City, Bolton, Chelsea)
113: Ian Wright (Arsenal, West Ham)
111: Emile Heskey (Leicester, Liverpool, Birmingham, Wigan, Aston Villa)
111: Dion Dublin (Man Utd, Coventry, Aston Villa)
109: Jermaine Defoe (Tottenham, Portsmouth, West Ham)
106: Ryan Giggs (Man Utd)
102: Matthew Le Tissier (Southampton)
100: Darren Bent (Charlton, Tottenham, Sunderland, Aston Villa)

First Division*: 
357: Jimmy Greaves (-photo-, Chelsea, Tottenham, West Ham)
317: Stephen Bloomer (Derby County, Middlesbrough)
310: William "Dixie" Dean (Tranmere, Everton)
287: Gordon Hodgson (Liverpool, Aston Villa, Leeds)
257: Charlie Buchan (Sunderland, Arsenal)
255: Nat Lofthouse (Bolton)
248: Joe Bradford (Birmingham)
246: Hugh Gallacher (Newcastle, Chelsea, Derby, Grimsby)
243: Joe Smith (Bolton)
*) highest division in English football until the creation of the Premier League in 1992

All Football League Divisions (and Premiership):
434: Arthur Rowley (-photo-, WBA, Fulham, Leicester, Shrewsbury)
379: William "Dixie" Dean (Tranmere, Everton, Notts County)
357: Jimmy Greaves (Chelsea, Tottenham, West Ham)
352: Steve Bloomer (Derby, Middlesbrough)
345: George Camsell (Durham City, Middlesbrough)
330: John Aldridge (Newport, Oxford, Liverpool, Tranmere)
315: John Atyeo (Portsmouth, Bristol City)
315: Joe Smith (Bolton, Stockport)
312: Vic Watson (West ham, Southampton)
308: Harry Bedford (Nott'm Forest, Blackpool, Derby,  Newcastle, Sunderland, Bradford PA, Chesterfield)
307: Harry Johnson (Sheff Utd, Mansfield)
296: Hugh Gallacher (Newcastle, Chelsea, Derby County, Notts County, Grimsby, Gateshead)
294: Gordon Hodgson (Liverpool, Aston Villa, Leeds)
292: Cliff Holton (Arsenal, Watford, Northampton, Crystal Palace, Watford, Charlton, Orient)
290: Jimmy Hampson  (Nelson, Blackpool)